Cartoon Network’s cult classic finally makes the leap from animation to live-action, and the result is a gleefully chaotic, neon-charged adventure that balances nostalgia with modern spectacle. Dexter’s Laboratory (2025) doesn’t just recreate the cartoon—it reinvents it, throwing its boy genius into a live-action sandbox filled with rogue inventions, malfunctioning robots, and family-sized doses of heart.

At the center of it all is Jacob Tremblay as Dexter, a performance equal parts hilarious and sincere. Tremblay perfectly captures Dexter’s oversized ego, quick wit, and endless exasperation, while grounding him with the vulnerability of a kid who’s still figuring himself out. His rapid-fire delivery and manic energy feel ripped straight from the cartoon, yet nuanced enough to carry a feature-length film.
Balancing Dexter’s intensity is McKenna Grace as Dee Dee, the wide-eyed whirlwind of curiosity and chaos. Grace nails Dee Dee’s boundless energy, turning her into both a source of comic relief and the unlikely heart of the story. Their sibling rivalry provides the film’s funniest moments—slapstick pratfalls, “button-pushing” disasters, and constant bickering—yet it also forms the emotional core of the narrative.

The plot kicks into gear when Dexter’s latest experiment tears a rift in reality, unleashing the hidden horrors of his laboratory into the sleepy suburban neighborhood. Rogue inventions parade through the streets like bizarre, weaponized toys: jet-powered hamsters, malfunctioning clones, and a robot army with defective programming. These sequences are a visual feast, blending practical effects with slick CGI to create a world that feels chaotic yet tangible.
Bill Hader’s Professor Utonium is a welcome addition, serving as both a mentor figure and comic foil. His dry delivery contrasts hilariously with Dexter’s arrogance, while also expanding the universe with nods to other iconic Cartoon Network properties. His presence hints at a shared world without overwhelming the story, offering fans a clever wink without losing focus.
Awkwafina’s turn as the voice of the rogue AI inside Dexter’s lab is another standout. Equal parts menacing and sarcastic, her line delivery injects a layer of unpredictability into the film. She embodies the “voice of chaos,” mocking Dexter’s flaws while pushing the story toward its most outrageous set pieces. The result is an antagonist who feels uniquely fitting for Dexter’s brand of self-inflicted madness.

Director Chris McKay brings a sense of kinetic energy to every scene, infusing the film with the same anarchic spirit that made the original cartoon so beloved. From fast-paced chase sequences through collapsing laboratories to surreal dreamscapes inside the portal itself, McKay ensures that the action never drags. His background in animated comedies (The LEGO Batman Movie) shines through, balancing absurdity with genuine emotional beats.
What sets Dexter’s Laboratory (2025) apart from being just a loud, effects-driven comedy is its surprising heart. Beneath the gadgets and gags lies a story about family, humility, and teamwork. Watching Dexter slowly realize that genius alone cannot fix the world—while Dee Dee demonstrates the power of empathy and intuition—gives the chaos an emotional anchor. The siblings’ growth feels earned, even amidst the most ridiculous sci-fi set pieces.
Visually, the film is a neon playground. The production design leans into retro-futurism, with the lab’s gadgets glowing in candy-colored palettes, contrasted against the warm, grounded tones of suburban life. This aesthetic choice creates a striking contrast between the “normal world” and the manic brilliance bubbling beneath it. Combined with a punchy synth-heavy score, the movie feels like stepping into a Saturday morning cartoon turned blockbuster.

The humor lands on multiple levels, appealing to kids with slapstick mayhem while offering adults sharp, self-aware jokes about science, technology, and childhood nostalgia. It’s a film that doesn’t talk down to its audience, instead celebrating the absurdity of both genius and chaos.
Ultimately, Dexter’s Laboratory (2025) succeeds because it never loses sight of what made the original special: the wild tension between invention and imagination, sibling rivalry and sibling love. With a stellar cast, inventive visuals, and a story that balances heart with hilarity, it’s a movie that feels as fresh as it does nostalgic.
⭐ Rating: 8.6/10 — A laugh-out-loud, gadget-packed joyride that proves even in live action, Dexter’s lab is still the most chaotic place on Earth.